منابع مشابه
What's the (end) point?
Clinicians caring for children or adults with pulmonary arterial hypertension (PAH) face a number of challenges, not the least of which is determining whether a patient has met treatment targets based on changes in a given test (such as the 6-min walk distance (6MWD)) and whether these changes translate to meaningful improvements in that patient's quality of life or survival. While several trea...
متن کاملVariable End Point Problem
The variational derivative of a functional J[y] can be defined as δJ/δy = F y (x, y, y ′)− d dx F y ′ (x, y, y ′) [1, pp. 27–29]. Euler's equation essentially states that the variational derivative of the functional must vanish at an extremum. This is analogous to the well-known result from calculus that the derivative of a function must vanish at an extremum. In this section, we consider a sim...
متن کاملEnd-point nystagmus.
Infrared oculography was performed during sustained lateral gaze in 12 normal subjects to investigate end-point nystagmus while fixating a target light. Five failed to develop nystagmus despite deviation up to 40 degrees from 4 to 5 min. Six subjects developed nystagmus immediately or shortly after reaching the deviated position. In one, the nystagmus (0.5 degrees to 1 degree and 1.0 Hz) began ...
متن کاملCommentary: The end of the hygiene hypothesis?
Three years ago, we published a commentary in the International Journal of Epidemiology, which concluded that the observed increases in asthma prevalence in Western countries had peaked or even begun to decline. Further evidence for this is presented in the paper by Ponsonby et al. that appears in the current issue of the journal. However, although there is now substantial evidence that the ‘ep...
متن کاملThe Role of Receptor for Advanced Glycation End Products in Airway Inflammation in CF and CF related Diabetes
Cystic Fibrosis (CF) is often accompanied by diabetes leading to worsening lung function, the reason for which is unclear. The receptor for advanced-glycation-end-products (RAGE) regulates immune responses and inflammation and has been linked to diabetes and possibly CF. We performed a pilot study to determine if CF and CF-related diabetes (CFRD) are associated with enhanced RAGE expression. Fu...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2016
ISSN: 1569-1993
DOI: 10.1016/j.jcf.2016.06.003